GenomeAsia 100K is a unique partnership between academia, research organizations and private companies bringing together the rigor of academic research with the goal driven approach of private companies. The first stage of our project will sequence 10,000 Asian individuals for ethnic stratification within each local ancestry. This will be followed by sequencing of 90,000 individuals combined with clinical and phenotype information to find unique Asian variants. The 100,000 whole genome sequences from 28 different countries will accelerate precision medicine applications for Asian patients. Further, the unique genetic diversity prevalent in South, North and East Asia provides a valuable source for clinical insights that should enhance our understanding of disease biology; from rare inherited disease to common and genetically complex diseases such a cancer, diabetes and cardiovascular disease.